Oh, there are definitely fandoms where you can reasonably write Serious Business 'experimented on by evil scientists'. Lost would do, as would any Stargate. Anywhere completely ridiculous plots are done with a straight face in canon.
Fear of clowns, maybe not. Unless you're talking It fanfic... which.... hey, does that exist? It should.
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Fear of clowns, maybe not. Unless you're talking It fanfic... which.... hey, does that exist? It should.